Exocrine: the vast majority of tumors of the pancreas arise in the exocrine part and these cancers look like pancreatic ducts under the microscope.Tumors can arise in either component, exocrine or endocrine. Endocrine: when tumors destroy the endocrine function of the pancreas, patients can develop sugar diabetes (abnormally high blood sugar levels).Exocrine: when tumors block the exocrine system, patients can develop pancreatitis and pain from the abnormal release of digestive enzymes into the substance of the pancreas instead of into the bowel, and they can develop digestive problems, such as diarrhea, from the incomplete digestion of food.Large tumors of the pancreas will interfere with both of these important bodily functions. Understanding the two functions of the pancreas is important because: Blood sugar is used by the body for energy. These endocrine cells release hormones such as insulin and glucagon into the blood stream, which maintain the proper level of sugar (glucose) in the blood. The islands are called the islets of Langerhans. The endocrine pancreas is composed of small islands of endocrine (endo=within) cells. The second functional component of the pancreas is the "endocrine" pancreas.
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